NASA Spaceline Present Awareness List #1,041 17 March 2023 (Space Life Science Analysis Outcomes)
SPACELINE Present Awareness Lists are distributed by means of listserv and are out there on the NASA Process Book site at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Present Awareness Senior Editor, [email protected].
Contact for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an short article that has not too long ago published or will publish in the upcoming weeks inside a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your short article to the e-mail address pointed out above. Articles received by Wednesday will seem inside that week’s list—articles received just after Wednesday will seem the following week.
Papers deriving from NASA assistance:
Freeborn TJ, Critcher S, Hooper G.
Segmental tissue resistance of healthier young adults in the course of 4 hours of six-degree head-down-tilt positioning.
Sensors (Basel). 2023 Mar 323(five):2793.
Note: Head-down tilt study. This short article might be obtained on the net with out charge.
Journal Effect Aspect: 3.847
Funding: “This analysis was supported by funding from the Alabama NASA EPSCoR FY19 Analysis Infrastructure Improvement, grant 80NSSC19M0051.”
Lawrence LM, Salary RR, Miller V, Valluri A, Denning KL, Case-Perry S, Abdelgaber K, Smith S, Claudio PP, Day JB.Osteoregenerative possible of 3D-printed poly ε-caprolactone tissue scaffolds in vitro utilizing minimally manipulative expansion of main human bone marrow stem cells.
Int J Mol Sci. 2023 Mar 324(five):4940.
Note: This short article might be obtained on the net with out charge.
Journal Effect Aspect: 6.208
Funding: “The present research have been partially funded by a Marshall University translational analysis award (to P.P.C.) In addition, this analysis operate was partially funded by the NASA Established Plan to Stimulate Competitive Analysis (EPSCoR)—Rapid Response Analysis, Grant #80NSSC22M0249 (to R.S.).”
Flatt AJ, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Ilany S, Matus A, Malone SK, Goel N, Jang S, Weimer J, Lee I, Rickels MR.
Automated insulin delivery for hypoglycemia avoidance and glucose counterregulation in extended-standing kind 1 diabetes with hypoglycemia unawareness.
Diabetes Technol Ther. 2023 Feb 24. On line ahead of print.
PI: N. Goel
Journal Effect Aspect: 7.337
Funding: “This operate was supported by Public Wellness Service analysis grants R01 DK091331 (to M.R.R.), UL1 TR001878 (University of Pennsylvania Center for Human Phenomic Science), P30 DK19525 (University of Pennsylvania Diabetes Analysis Center), K99NR017416 (to S.K.M.), and R01 DK11788 (to N.G.) National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 (to N.G.) Pennsylvania Division of Wellness grant SAP 4100079750 (to I.L.) the Charles B. Humpton, Jr. Endowed Fellowship in Diabetes Analysis (to A.J.F.) and the Human Metabolism Resource of the University of Pennsylvania Institute for Diabetes, Obesity & Metabolism. Medtronic supplied discounted 670G insulin pumps and glucose monitoring devices for the study by means of investigator-initiated grant NERP16-015 (to M.R.R.).”
Mogul R, Miller DR, Ramos B, Lalla SJ.
Metabolomic and cultivation insights into the tolerance of the spacecraft-related Acinetobacter toward Kleenol 30, a cleanroom floor detergent.
Front Microbiol. 2023 Mar 614:1090740.
Note: This short article is component of Analysis Subject “The Effect of the Space Atmosphere on Microbial Development and Behavior” (https://www.frontiersin.org/analysis-subjects/27130/the-influence-of-the-space-atmosphere-on-microbial-development-and-behavior#overview). The Analysis Subject also incorporates articles from prior Present Awareness List #1,009 https://doi.org/ten.3389/fmicb.2022.877625, https://doi.org/ten.3389/fmicb.2022.893071, and https://doi.org/ten.3389/fmicb.2022.909997. More articles will be forthcoming and might be discovered in the hyperlink to the Analysis Subject. This short article might be obtained on the net with out charge.
Journal Effect Aspect: 6.064
Funding: “This operate was supported by a grant (NNH18ZDA001N) from the Planetary Protection Analysis element of the National Aeronautics and Space Administration (NASA) Analysis Possibilities in Space and Earth Sciences plan.”
Tyson TL, Flynn-Evans EE, Stone LS.
Differential saccade-pursuit coordination below sleep loss and low-dose alcohol.
Front Neurosci. 2023 Feb 1616:1067722.
Note: This short article appeared in final week’s Present Awareness list and it is appearing once again to incorporate the create-up of the short article from author L.S. Stone: “This study demonstrates that eye-movement-primarily based overall performance metrics (oculometrics) are sensitive adequate to detect compact deficits and precise adequate to distinguish possible causes. Especially, low-dose alcohol (< .05% BAC) benefits in impairment of the cortically controlled pursuit technique though sleep loss (24 hours awake) impacts cortical, midbrain, and brainstem regions that manage each pursuit and the saccadic backup technique. Oculometrics also showed that caffeine largely mitigates pursuit deficits from sleep loss but does not restore standard saccades. These findings validate the possible use of oculometrics for the detection/diagnosis of mild neural impairment in operational settings and the assessment of countermeasure efficacy.” This short article might be obtained on the net with out charge.
Journal Effect Aspect: 5.152
Funding: “This analysis was supported by the Workplace of Naval Analysis (ONR), NASA’s Human Analysis Plan (HRP), and Ames Center Innovation Fund (CIF).”
Other papers of interest:
Kuldavletova O, Navarro Morales DC, Quarck G, Denise P, Clément G.
Spaceflight alters reaction time and duration judgment of astronauts.
Front Physiol. 2023 Mar 1714:1141078.
Note: ISS benefits. This short article is component of Analysis Subject “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/analysis-subjects/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). More articles will be forthcoming and might be discovered in the hyperlink to the Analysis Subject. This short article might be obtained on the net with out charge.
Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, Longo F, Salvioli S, Lau P, Moeller R, Jordan J, Illig T, Villanueva MM, Gruber M, Bürkle A, Franceschi C, Rittweger J.
Extended-term human spaceflight and inflammaging: Does it market aging?
Ageing Res Rev. 2023 Mar 12101909. Evaluation.
Note: From the abstract: “Spaceflight and its related stressors, such as microgravity, radiation exposure, confinement, circadian derailment, and disruptive workloads represent an unprecedented kind of exposome that is completely novel from an evolutionary stand point. Inside this viewpoint, we aimed to critique the effects of prolonged spaceflight on immune-neuroendocrine systems, brain and brain-gut axis, cardiovascular technique and musculoskeletal apparatus, highlighting in distinct the similarities with an accelerated aging method.”
Ghosh D, Verma E, Gershman S, Anderson T, Kumar Ghosh R, Peter M.
Central nervous technique in the course of human spaceflight missions to Mars. A meta-evaluation.
Int J Med Sci Clin Invent. 2023 Jan 1510(01):6411-50.
Note: From the abstract: “The benefits of far more than 50 years of space-connected neuroscience research on persons and animals subjected to spaceflight or settings that are related to spaceflight are reviewed in this short article, along with their implications and the future operate required to make sure profitable Mars missions.” This short article might be obtained on the net with out charge.
Ghosh D, Verma E, Kumar Ghosh R, Gershman S, Anderson T, Peter M.
Challenges and possibilities for neuroscience in the context of spaceflight and the central nervous technique.
Int J Med Sci Clin Invent. 2023 Jan 1510(01):6397-410.
Note: From the short article: “We give a summary of what is at the moment identified about the influence of microgravity on the central nervous technique (CNS), each in human and cellular models, primarily based on actual spaceflight and parabolic flight investigations as nicely as ground-primarily based approaches acceptable for microgravity-primarily based analysis. On top of that, we investigate the influence of microgravity on the biology of tumor cells in this critique, concentrating on brain tumor cells, in order to supply a fresh viewpoint on the study of cancer and somewhat novel therapeutic approaches.” This short article might be obtained on the net with out charge.
Marfia G, Guarnaccia L, Navone SE, Ampollini A, Balsamo M, Benelli F, Gaudino C, Garzia E, Fratocchi C, Di Murro C, Ligarotti GK, Campanella C, Landolfi A, Perelli P, Locatelli M, Ciniglio Appiani G.
Microgravity and the intervertebral disc: The influence of space situations on the biomechanics of the spine.
Front Physiol. 2023 Mar 1414:1124991. Evaluation.
Note: From the short article: “In the present operate, the mechanisms of disc degeneration, the situations of microgravity, and their association have been discussed in order to recognize probable molecular mechanisms underlying disc degeneration and the connected clinical manifestations in order to create a model of prevention to sustain overall health and overall performance of air- and space-travelers. The concentrate on microgravity also makes it possible for the improvement of new proofs of idea with possible therapeutic implications.” This short article might be obtained on the net with out charge.
Thoolen SJJ, Kuypers M.
External hemorrhage manage tactics for human space exploration: Lessons from the battlefield.
Wilderness Environ Med. 2023 Mar 9. Evaluation. On line ahead of print.
Aventaggiato M, Barreca F, Vitiello L, Vespa S, Valente S, Rotili D, Mai A, Lotti LV, Sansone L, Russo MA, Bizzarri M, Ferretti E, Tafani M.
Part of SIRT3 in microgravity response: A new player in muscle tissue recovery.
Cells. 2023 Feb 2212(five):691.
Note: A rotary cell culture technique was utilized in this study. This short article and the short article under (Dubayle et al.) are component of Unique Challenge “New Insights into Microgravity and Space Biology” (https://www.mdpi.com/journal/cells/particular_troubles/R75D12X7FZ). The Unique Challenge also incorporates articles from prior Present Awareness Lists #1,028 https://doi.org/ten.3390/cells11233871and #1,032 https://doi.org/ten.3390/cells12020246. More articles will be forthcoming and might be discovered in the hyperlink to the Unique Challenge. This short article might be obtained on the net with out charge.
Dubayle D, Vanden-Bossche A, Peixoto T, Morel JL.
Hypergravity increases blood-brain barrier permeability to fluorescent dextran and antisense oligonucleotide in mice.
Cells. 2023 Feb 2412(five).
Note: This short article and the short article above (Aventaggiato et al.) are component of Unique Challenge “New Insights into Microgravity and Space Biology” (https://www.mdpi.com/journal/cells/particular_troubles/R75D12X7FZ). This short article might be obtained on the net with out charge.
Cui Y, Liu W, Zhao S, Zhao Y, Dai J.
Advances in microgravity directed tissue engineering.
Adv Healthc Mater. 2023 Mar 9e2202768. Evaluation. On line ahead of print.
Note: From the abstract: “Here, the existing status, current advances, challenges, and prospects of microgravity connected to tissue engineering are reviewed.”
Ismaeel A, Van Pelt DW, Hettinger ZR, Fu X, Richards CI, Butterfield TA, Petrocelli JJ, Vechetti IJ, Confides AL, Drummond MJ, Dupont-Versteegden EE.
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy.
Skelet Muscle. 2023 Mar 1013:six.
Note: Hindlimb unloading study.
Vilchinskaya N, Lim WF, Belova S, Roberts TC, Wood MJA, Lomonosova Y.
Investigating eEF2k/eEF2 pathway regulation and its part in protein synthesis impairment in the course of disuse-induced skeletal muscle atrophy.
Am J Pathol. 2023 Mar 3S0002-9440(23)00060-three. On line ahead of print.
Wang Y, Liu H, Wei H, Wu C, Yuan F.
The impact of a knee brace on muscle forces in the course of single-leg landings at two heights.
Int J Environ Res Public Wellness. 2023 Mar 620(five):4652.
Note: From the abstract: “Single-leg landing is 1 of the maneuvers that has been linked to non-make contact with anterior cruciate ligament (ACL) injuries, and wearing knee braces has been shown to lessen ACL injury incidence. The objective of this study was to identify irrespective of whether wearing a knee brace has an impact on muscle force in the course of single-leg landings at two heights by means of musculoskeletal simulation.” This short article might be obtained on the net with out charge.
Liu CJ, Yang X, Wang SH, Wu XT, Mao Y, Shi JW, Fan YB, Sun LW.
Stopping disused bone loss by means of inhibition of sophisticated glycation finish solutions.
Int J Mol Sci. 2023 Mar 324(five):4953.
Note: This short article is component of Section “Biochemistry” (https://www.mdpi.com/journal/ijms/sections/biochemistry) and might be obtained on the net with out charge.
Guez-Barber D, Colon LM, Raphael D, Wragan MA, Yun S, Eisch AJ.
Female and male microglia are not unique in the dentate gyrus of postnatal day ten mice.
Neuroscience Letters. 2023 Mar 8137171.
Note: From the abstract: “Microglia, the resident immune cells of the brain, assistance standard brain function and the brain’s response to illness and injury. The hippocampal dentate gyrus (DG) is an region of microglial study due to its central part in numerous behavioral and cognitive functions. Interestingly, microglia and connected cells are distinct in female vs. male rodents, even in early life. Certainly, postnatal day (P)-dependent sex variations in quantity, density, and morphology of microglia have been reported in particular hippocampal subregions at precise ages. Having said that, sex variations in the DG have not however been assessed at P10, a rodent developmental time point translationally relevant to human term gestation. To address this information gap, Iba1+ cells in the DG (which are enriched in the Hilus and Molecular Layer) in female and male C57BL/6J mice have been analyzed for their quantity (by means of stereology) and density (by means of stereology and by means of sampling).”
Cariati I, Bonanni R, Rinaldi AM, Marini M, Iundusi R, Gasbarra E, Tancredi V, Tarantino U.
Recombinant irisin prevents cell death and mineralization defects induced by random positioning machine exposure in main cultures of human osteoblasts: A promising tactic for the osteoporosis therapy.
Front Physiol. 2023 Mar 1514:1107933.
Note: A random positioning machine was utilized in this study.
Ge YX, Zhuang HJ, Zhang TW, Liang HF, Ding W, Zhou L, Dong ZR, Hu ZC, Chen Q, Dong J, Jiang LB, Yin XF.
Precise manipulation of circadian clock utilizing MnOtwo
nanocapsules to amplify photodynamic therapy for osteosarcoma.
Mater Nowadays Bio. 2023 Apr19:100547.
Zhang P, Yan J, Liu Z, Zhou Q.
Impeded frontal-occipital communications in the course of Go/Nogo tasks in humans owing to mental workload.
Behav Brain Res. 2023 Feb 13438:114182.
Note: From the abstract: “Human brains rely on oscillatory coupling mechanisms for regulating access to prefrontal cognitive sources, dynamically communicating in between the frontal and remote cortex. We be concerned that communications across cortical regions will be impeded when humans in intense space environments travel with mental load operate, affecting the profitable completion of missions. Right here, we monitored crews of workers performing a Go/Nogo activity in space travel, accompanied by acquisitions of electroencephalography (EEG) signals.”
Cavelli ML, Mao R, Findlay G, Driessen K, Bugnon T, Tononi G, Cirelli C.
Sleep/wake adjustments in perturbational complexity in rats and mice.
iScience. 2023 Mar 1726(three):106186.
Note: From the abstract: “In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses utilizing Perturbational Complexity Index (PCI) and connected PCIst
(st, state transitions). Right here, we validate PCIst
in freely moving rats and mice by displaying that it is reduce in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans.” This short article might be obtained on the net with out charge.