FivepHusion Announces Strategic Collaboration with Treehill Partners and Syneos Well being

Supporting FivepHusion’s International Improvement and Commercialization Method

SYDNEY, May perhaps 26, 2023 /PRNewswire/ — FivepHusion, an sophisticated clinical-stage biotechnology business, nowadays announced its collaboration with Treehill Partners, a New York-primarily based strategic and monetary advisory firm specializing in healthcare market transactions, and Syneos Health® (Nasdaq: SYNH), a top completely integrated biopharmaceutical options organization, to create and bring a novel, enhanced chemotherapeutic item to marketplace.

Treehill Partners will help FivepHusion with integrated company improvement, operational, strategic and transactional knowledge. Syneos Well being will help FivepHusion’s integrated clinical improvement and commercialization capabilities. This collaboration is developed to strategically and optimally progress improvement and commercialization of FivepHusion’s enhanced chemotherapeutic formulation Deflexifol™ in international markets.

“This is a extremely thrilling time for FivepHusion. We are at a vital stage in our development technique. By collaborating with Treehill Partners and Syneos Well being, we think we are positioned to effectively bring our improvement function on Deflexifol™ to international markets, such as in the US, Europe and Asia,” mentioned Dr. Christian Toouli, CEO &amp Managing Director, FivepHusion. “This collaboration represents a distinctive functioning model to the market. By way of the combined strength and competency of 3 market leaders, we intend to maximize our progress on the improvement of Deflexifol™ and promptly bring revolutionary oncology medicines to individuals in will need.”

“We’re excited to collaborate with FivepHusion and Treehill Partners to enable bring Deflexifol™ to individuals,” mentioned Christian Tucat, Chief Small business Officer, Syneos Well being. “Leveraging our deep therapeutic and international knowledge, Syneos Well being is pleased to contribute to accelerating the clinical improvement and commercialization of this significant new therapy.”

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“This collaboration represents a new model of integrated solutions across disciplines, developed to permit US and non-US emerging players to play a important function on the international stage, and we’re proud to function alongside FivepHusion and Syneos Well being,” mentioned Ali Pashazadeh, Companion &amp Co-founder, Treehill Partners. “By merging the scientific prowess of our customers with the clinical and industrial knowledge of Syneos Well being and Treehill’s healthcare advisory and execution capabilities, we are offering a distinctive ecosystem developed to enable businesses to flourish in spite of the present difficult marketplace atmosphere.”

About FivepHusion

FivepHusion (www.fivephusion.com) is an sophisticated clinical-stage, globally focused biotechnology business whose goal is to optimize chemotherapy to increase patient therapy outcomes and excellent of life.

FivepHusion is creating Deflexifol™, a proprietary, novel, and optimized physiological pH formulation to co-administer the chemotherapeutic agent five-fluorouracil (five-FU) and its biomodulator leucovorin (LV), a drug that enhances five-FU anti-cancer activity. These drugs are normally employed globally to treat different strong tumors such as colorectal, pancreatic, gastric and breast cancers. Nevertheless, due to their chemical incompatibility, present formulations of five-FU and LV endure from limitations in their security, tolerability, effectiveness and pharmacological compatibility. These disadvantages contribute to restricted therapy response prices, unpleasant side effects and toxicities, and a decreased excellent of life knowledgeable by cancer individuals. Deflexifol™ has been developed to address these limitations via co-administration of the two agents with clinically demonstrated improvements in security and tolerability and the prospective to give superior anti-tumor efficacy, improved excellent of life, and all round enhanced clinical advantage for cancer individuals.

FivepHusion is creating Deflexifol™ by means of the FDA 505(b)(two) and EMA Report 10b regulatory pathways as a bioequivalent, chemotherapy replacement of sub-optimal common of care formulations of five-FU and LV for the therapy of metastatic colorectal cancer, and other tumors with a projected international incidence of higher than six million individuals. Deflexifol™ is also becoming created as a new therapy for cancers with higher unmet health-related will need, such as pediatric ependymoma a uncommon and deadly brain cancer which afflicts extremely young youngsters.

Deflexifol™ is a trademark of FivepHusion.

About Syneos Well being

Syneos Health® (Nasdaq: SYNH) is a top completely integrated biopharmaceutical options organization constructed to accelerate buyer good results.  Syneos translates distinctive clinical, health-related affairs and industrial insights into outcomes to address modern day marketplace realities.

Syneos brings with each other a talented group of pros, who function across far more than 110 nations, with a deep understanding of patient and doctor behaviors and marketplace dynamics. With each other Syneos shares insights, makes use of the most up-to-date technologies and applies sophisticated company practices to speed customers’ delivery of significant therapies to individuals.

Syneos Well being supports a diverse, equitable and inclusive culture that cares for colleagues, consumers, individuals, communities and the atmosphere.

To study far more about how Syneos are Shortening the distance from lab to life®, take a look at syneoshealth.com or subscribe to our podcast.

About Treehill Partners

Treehill was founded in 2014 and is led by companion and co-founder Ali Pashazadeh, who previously headed Blackstone’s healthcare advisory group and UBS’ European biotech coverage.

Treehill supports customers in the healthcare market all through the asset lifecycle, from purchase-side acquisition and investment more than worth make and development to sell-side disposal and divestment. Important places of concentrate are the identifying and executing of worth inventive transactions and their knitting into prosperous corporate evolution tactics.

In delivering its guidance, the firm employs a multidisciplinary senior group with impeccable pedigree that comprises health-related physicians/ MDs, scientists/ PhDs, CEOs of biotechs, senior executives from huge pharma, and knowledgeable technique consultants and investment bankers. Solutions supplied are centered about the “principal mentality” of the group, delivering actionable strategic and transaction guidance that matters to CEOs, senior leadership, their stakeholders and investors.

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